Figure 5 | Scientific Reports

Figure 5

From: Variation in pentose phosphate pathway-associated metabolism dictates cytotoxicity outcomes determined by tetrazolium reduction assays

Figure 5

Endpoint-specific Sensitivity to SIRT Inhibitors. (g–j) Beas-2B cells treated with 1 µM or 10 µM B[a]P for 48 h in the presence of 10 µM AGK2 (SIRT2 Inhibitor) or 0.5 µM EX527 (SIRT1 Inhibitor), followed by (a) WST1 metabolism, (b) EdU uptake in EdU + cells, (c) cumulative cell cycle phase quantitation, and (d) magnitude changes in each cell cycle relative to respective vehicle- and inhibitor-only control (R. Ctrl). n = 3. Endpoints are the arithmetic mean of listed independent experiments with error bars denoting one standard error of the mean.

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