Table 1 Modeled 6-Aminonicotinamide IC50 Values.

From: Variation in pentose phosphate pathway-associated metabolism dictates cytotoxicity outcomes determined by tetrazolium reduction assays

Endpoint

IC50 (M)

CI95% (M)

Protein

 > 10 × 10–5*

 > 10 × 10–5*

Alamar Blue

 > 10 × 10–5*

 > 10 × 10–5*

MTT

4.1 × 10–6

2.7 × 10–6–5.4 × 10–6

MTS

1.6 × 10–7

1.5 × 10–7–1.7 × 10–7

WST1

6.9 × 10–8

5.7 × 10–8–8.1 × 10–8

  1. *6-Aminonicotinamide did not reduce endpoint below 50% relative to vehicle controls up to the highest concentration of > 10–5 M.
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