Figure 2
From: Impact of elastic substrate on the dynamic heterogeneity of WC256 Walker carcinosarcoma cells
(A) Subpopulations transitions observed in migrating cells of WC256 adherent subline. The main transition path marked with solid arrows starts from mesenchymal and goes through polygonal and bigonal to amoeboid subpopulation. Direct transition between mesenchymal and amoeboid subpopulation (marked with dashed arrows) was observed as well, although very rarely (3% of all observed cells). (B) Exemplary transition between mesenchymal and polygonal form. (C) Exemplary transition between amoeboid and polygonal form. Time scale in minutes:seconds, scalebar = 25 µm. Dynamic behaviors of the same cells are presented in Supplementary Video S3.
