Figure 3
From: Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in gastric cancer
Differences between metabolic subtypes. (A) Top 20 mutated genes in all gastric cancer patients of TCGA-STAD cohort. (B) Top 20 differentially mutated genes in all gastric cancer patients of TCGA-STAD cohort. (C) Comparison of TCGA gastric cancer subtypes among two metabolic subtypes. (D) comparison of tumor mutation burden among two metabolic subtypes. (E) KEGG signaling pathway enriched for genes with low methylation and high expression in cluster 2. (F) KEGG signaling pathway enriched for genes with low methylation and high expression in cluster 1. (G) Stromal score, Immune score and ESTIMATE score between two metabolic subtypes. (H) Relative proportion of 22 infiltrating immune cells estimated by CIBERSORT between two metabolic subtypes of TCGA-STAD cohort. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
