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Figure 2

From: Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1–7) axis via NF-κB/MAPK pathway

Figure 2

Overexpression of ACE2 mediated activation of ACE2/Ang-(1–7) axis. (A) Western blotting analysis (left) and quantification of the expression of ACE2 (middle histogram) and AT1R (right histogram) in the lung tissue. (B, C) Ang II and Ang-(1–7) levels in lung tissues were detected using enzyme-linked immunosorbent assay. D, mRNA levels of MasR in the lung tissue. *Compared with the control group, p < 0.05, **p < 0.01. ***p < 0.001. #Compared with the IR group, p < 0.05, ##p < 0.01. &Compared with AAV-ACE2 group, p < 0.05, && p < 0.01. ACE2: angiotensin-converting enzyme 2; Ang, angiotensin; AT1R, angiotensin II type 1 receptor; IR, irradiation; MasR, Mas receptor.

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