Figure 4 | Scientific Reports

Figure 4

From: Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1–7) axis via NF-κB/MAPK pathway

Figure 4

Captopril and valsartan mediated activation of ACE2/Ang-(1–7) axis. (A) Expression levels of ACE2, AT1R, and ACE in the lung tissue. (B) Levels of Ang II in the lung tissue. (C) Levels of Ang-(1–7) in the lung tissue. (D) mRNA levels of MasR in the lung tissue. *Compared with the control group, p < 0.05. #Compared with the IR group, p < 0.05, ## p < 0.01. ACE: angiotensin-converting enzyme; ACE2: angiotensin-converting enzyme 2; Ang, angiotensin; AT1R, angiotensin II type 1 receptor; IR, irradiation; MasR, Mas receptor.

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