Table 2 Lung function parameters of C57BL/6 mice in each group.

From: Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1–7) axis via NF-κB/MAPK pathway

Groups

TVb (ml)

MVb (ml/min)

PIFb (ml/s)

PEFb (ml/s)

EF50 (ml/s)

Control

0.29 ± 0.02

138.13 ± 17.87

10 ± 0.9

6.07 ± 0.77

0.4 ± 0.07

IR

0.24 ± 0.02***

107.61 ± 16.3**

8.09 ± 0.87***

4.95 ± 0.79*

0.3 ± 0.06***

AAV-NC

0.24 ± 0.02

113.04 ± 15.22

8.4 ± 0.95

5.28 ± 0.57

0.32 ± 0.04

AAV-ACE2

0.27 ± 0.01#

123.51 ± 8.41#

9 ± 0.59#

5.8 ± 0.72#

0.37 ± 0.02#

AAV-ACE2 + A779

0.24 ± 0.01&&

112.1 ± 9.05&

8.22 ± 0.45&

4.92 ± 0.57&

0.32 ± 0.02&

  1. TVb: Tidal Volume (box); MVb: Minute Volume (box); PIFb: Peak Inspiratory Flow (box); PEFb: Peak Expiratory Flow (box); EF50: Expiratory Flow at the point 50% of TV. Compared with the control group, *indicates p < 0.05, **p < 0.01, ***p < 0.001. Compared with IR group, #p < 0.05. Compared with AAV-ACE2 group, & indicates p < 0.05, &&p < 0.01.
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