Figure 6 | Scientific Reports

Figure 6

From: LncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing

Figure 6The alternative text for this image may have been generated using AI.

FAS-AS1 promotes apoptosis through regulating mitochondria function and Fas splicing. (a) Representative picture of Mito-Tracker red labeled mitochondria in FAS-AS1 overexpressed cells or control cells. (b) Quantitative analysis of the representative picture’s fluorescence intensity. (c) Microstructure of mitochondria was observed by TEM in FAS-AS1 overexpressed cells or control cells. (d) Relative expression of sFas was determined by RT-qPCR 24 h after transfection with FAS-AS1 vector or control vector. (e) Relative expression of mFas was determined by RT-qPCR 24 h after transfection with FAS-AS1 vector or control vector. (f) The expression of several cell apoptosis signal regulators (cleaved-caspase 3, Bcl-2 and Bax) were examined by western blotting after transfection with FAS-AS1 vector or control vector. (g) The quantification of cleaved-caspase 3. (h) The quantification of Bax/Bcl-2. *P < 0.05, **P < 0.01.

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