Figure 2 | Scientific Reports

Figure 2

From: Cardiovascular characterisation of a novel mouse model that combines hypertension and diabetes co-morbidities

Figure 2

Oxidative stress analysis. (A) Urinary isoprostanes concentration over a 24 h period. (B) Cardiac Nox4 gene expression and (C) Quantificaiton of cardiac nitrotyrosine (NT) staining. Aortic tissue (D) Nox1, (E) Nox4 and (F) p47phox gene expression levels. (G–I) Cardiac (G) Nrf2, (H) NQO1 and (I) HO-1 antioxidant gene expression levels. Gene expression was determined by qRT-PCR and expressed relative to non-diabetic BPN mice. *P < 0.05 and **P < 0.01 as indicated. Bars represent mean ± SEM with individual values plotted. a.u = arbitrary units.

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