Figure 2 | Scientific Reports

Figure 2

From: Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts

Figure 2Figure 2

Histopathological and immunohistochemical findings of parental tumors and PDXs. (A,B) Left panels, HE staining. Middle and right panels present immunohistochemical staining of a serial section for each HE stained section on the left. HE; morphological characteristics, such as glandular structure and solid nests, are maintained in PDXs of endometrioid carcinoma cases (UXE-001 and UXE-005). (C,D) Sarcomatous components are prominent in PDXs of carcinosarcoma cases (UXE-004 and UXE-008). AE1/AE3; the positivity was almost maintained in PDXs (UXE-001, UXE-004, and UXE-005). PAX2; the proportions of positive cells gradually decreased in PDXs (UXE-001). ARID1A; the rate of positivity observed in the parental tumor tissues was almost maintained in the PDXs (UXE-005). PAX8; the proportions of positive cells gradually increased in PDXs (UXE-004). TP53 (wild-type pattern) and ARID1A (loss of expression); the staining patterns were almost maintained in PDXs (UXE-008). HE hematoxylin and eosin, TG1, 6 and 8 TransGeneration 1, 6 and 8. Bar = 100 μm.

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