Figure 3 | Scientific Reports

Figure 3

From: Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts

Figure 3

Immunohistochemical findings of parental tumors and PDX. (A) Immunohistochemical staining for ER. ER status switched from positive to negative in PDXs (UXE-001). (B) Immunohistochemical staining for TP53. TP53 staining was heterogeneous and partly positive (indicating a mutation in some cells), but PDXs showed wild-type expression patterns (UXE-005). (C) Immunohistochemical staining for PTEN. The proportions of PTEN-positive cells were increased in one case (UXE-005). ER estrogen receptor, TG1 and 6 TransGeneration 1 and 6. Bar = 100 μm.

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