Figure 7
From: Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates
Side-by-side comparison of combined binding energy inferences and thermal denaturation shift measurements for silvestrol, zotatifin, CR-1-31-B. All eIF4A1 variants known to be sensitive to rocaglates (blue) exhibited remarkably similar patterns for all three rocaglates. By contrast, the four rocaglate-resistant variants analyzed here (red) showed widely disparate patterns. The four variants for which no experimental determination of sensitivity to rocaglates exists (dark grey), showed two distinct patterns—one that was analogous to that of the sensitive patterns analyzed here, and three that were analogous among them and different from all other sensitive or resistant patterns.
