Figure 3
From: NCBP1 enhanced proliferation of DLBCL cells via METTL3-mediated m6A modification of c-Myc
NCBP1 increased the expression of METTL3 in DLBCL cells. (A) Volcano plot showing that the differentially expressed gene METTL3 was related to shNCBP1 in SU-DHL-4 cells. (B) RT‒qPCR verified that METTL3 was downregulated by shNCBP1. (C) METTL3 expression was significantly related to NCBP1 (r = 0.7; P < 0.0001) in DLBCL tissue (data from the GEPIA database). (D) The relationship between NBCP1 and METTL3 mRNA levels by RT‒qPCR analysis in DLBCL tumor samples. (E) The half-life (T1/2) of METTL3 mRNA in SU-DHL4 cells transfected with Lv-oeNCBP1, Lv-shNCBP1 and Lv -NC (the control lentivirus). Statistically significant differences were defined as follows: *P < 0.05; **P < 0.01, ***P < 0.001.
