Table 6 Effect of manganese (Mn) and manganese nanoparticles (Mn-NPs) on alanine amino transferase (ALT) and aspartate amino transferase (AST) in Pangasianodon hypophthalmus for a period of 96 h.

From: Multi biomarker approach to assess manganese and manganese nanoparticles toxicity in Pangasianodon hypophthalmus

Manganese exposure (mg/L)

Alanine amino transferase (ALT)

Aspartate amino transferase (AST)

Muscle

Liver

Gill

Kidney

Muscle

Liver

Gill

Kidney

Control (Mn-0, Mn-NPs-0)

4.60a ± 0.45

12.76a ± 0.58

10.34a ± 0.72

12.10a ± 0.66

6.64a ± 1.02

14.93a ± 0.73

12.40a ± 0.75

11.27a ± 1.95

Mn-110

9.88b ± 1.5

19.70b ± 1.10

15.78bc ± 0.80

19.53c ± 2.07

14.49c ± 1.23

21.26b ± 1.46

18.34b ± 1.06

17.16c ± 1.98

Mn-111

9.57b ± 1.18

23.82c ± 1.27

20.38c ± 1.57

21.62cd ± 0.97

18.04d ± 2.67

24.36c ± 2.06

22.00c ± 2.15

21.15d ± 1.44

Mn-112

13.83c ± 0.37

27.65d ± 1.20

25.39d ± 1.0

29.86e ± 1.22

19.81d ± 2.42

26.87 cd ± 0.82

24.70 cd ± 2.57

22.28d ± 1.94

Mn-113

16.36d ± 1.76

26.65d ± 0.38

25.45d ± 1.16

24.40d ± 2.38

25.11e ± 1.65

26.12 cd ± 2.18

23.05c ± 1.39

24.84e ± 2.27

Mn-114

24.38f ± 1.54

33.62e ± 1.08

23.03cd ± 1.15

32.02f. ± 2.68

24.96e ± 1.60

28.64d ± 0.57

25.47d ± 1.91

24.70e ± 2.48

Mn-NPs-91

8.79b ± 0.74

19.49b ± 0.89

13.92b ± 2.54

16.02b ± 1.25

10.89b ± 0.82

20.92b ± 1.39

17.59b ± 1.32

17.67c ± 1.44

Mn-NPs-92

12.73c ± 1.49

21.04bc ± 3.24

16.37bc ± 2.08

19.74c ± 1.97

13.44c ± 1.44

23.13c ± 1.62

21.69c ± 2.41

14.93b ± 1.72

Mn-NPs-93

16.49d ± 1.85

24.46c ± 1.35

25.19d ± 1.72

18.82bc ± 0.86

19.92d ± 2.58

26.24 cd ± 2.48

24.80 cd ± 2.70

16.86bc ± 3.88

Mn-NPs-94

16.58d ± 1.46

24.84c ± 2.89

23.06cd ± 2.11

20.61c ± 2.49

19.06d ± 2.28

24.01c ± 2.36

19.62b ± 3.40

14.99b ± 1.58

Mn-NPs-95

21.25e ± 3.34

36.12f ± 1.29

24.51d ± 1.37

25.75d ± 2.45

26.33e ± 5.06

25.85cd ± 2.38

21.66c ± 3.66

20.71d ± 2.79

p-value

< 0.01

< 0.01

< 0.01

< 0.01

< 0.01

< 0.01

< 0.01

< 0.01

  1. Values in the same column with different (a, b, c, d, e, f) differ significantly (p < 0.01). Data expressed as Mean ± SE (n = 6). ALT: nmole of sodium pyruvate formed/mg protein/min at 37 °C, AST: nmole Oxaloacetate released/min/mgproteinat37 °C.