Figure 4
MABsallo and MABsallo-VEGF play a role in slightly distinct pathways 3d after SVD: (A) PCA plot of top 500 most variable rlog-transformed genes. MABs treated urethras at 3d post-injury cluster together. (B) Hierarchical cluster heat map of Euclidian distance. (C) Venn Diagram of the number of DEGs (adj. p.val < 0.05 & |log2(fold-change)| > 1) expressed in each sample at 3d. The intersection shows the overlapping DEGs. There were no DEGs between MABsallo-VEGF vs MABsallo. (D) Heat map of all DEGs (adj. p.val < 0.05 & |log2(fold-change) |> 1) from rat urethra at 3d and 7d post-injury. PCA Principal component analysis, DEG differentially expressed genes, GO gene ontology, MABsallo allogeneic mesoangioblasts, MABsallo-VEGF VEGF-overexpressed allogeneic mesoangioblasts. Control group: saline injection.
