Figure 5
MABs promote neuromuscular regeneration and modulate inflammatory response: (A) Top 15 biological process GO-terms associated with upregulated and downregulated DEGs for both the MABsallo vs control and MABsallo-VEGF vs control at day 3. (B) Normalized gene count of individual genes involved in DNA methylation (Dnmt3a, Tet2), histone modification (Hdac1, Kat6a, Ehmt1, Kdm6a), myogenesis (Pax3, Pax7, Myh3), Rho GTPase/actin cytoskeleton organization (Arhgap31, Srgap1), myelination (Nrg1), neurogenesis (Sox2, Itga4, Igf2, Sox11), hypoxia (Hbb, Hba-a2) pro-inflammatory (C1qa, Il1b) and inhibition of axonal cone (Dio3, Efnb3). DEG differentially expressed genes, MABsallo allogeneic mesoangioblasts, MABsallo-VEGF VEGF-overexpressed allogeneic mesoangioblasts. Control group: saline injection. Data are shown as mean and StDev and individual data points.
