Table 1 Gene mutations identified in whole exome sequencing and validated by Sanger sequencing.

Dog 1

CCDC136

ENSCAFG00000023734

p.R870W

14

TP53

ENSCAFG00000016714

p.I151fs

5

Dog 2

BBX

ENSCAFG00000009867

p.D53Y

33

N4BP2

ENSCAFG00000015929

p.S1282F

3

PDGFRB

ENSCAFG00000018214

p.D881_I882delinsV

4

Dog 3

ATRX

ENSCAFG00000017252

p.L2119fs

X

GARNL3

ENSCAFG00000020142

p.R204*

9

HTR2C

ENSCAFG00000029120

p.R156H

X

NR3C2

ENSCAFG00000007813

p.R780*

15

NRXN3

ENSCAFG00000030472

p.V262A

8

SH3KBP1

ENSCAFG00000013075

p.R423*

X

TP53

ENSCAFG00000016714

p.D11fs

5

Dog 4

NAV3

ENSCAFG00000005746

p.A343T

15

PTPN11

ENSCAFG00000008894

p.G503V

26

ZMYM3

ENSCAFG00000017043

p.R295C

X

Dog 5

AKAP4

ENSCAFG00000015984

p.Q669*

X

ASMT

ENSCAFG00000024670

p.G168R

X

C7

ENSCAFG00000018608

p.L726S

4

CLCA4

ENSCAFG00000020244

p.M325T

6

COL11A1

ENSCAFG00000019985

p.P1193T

6

FBN1

ENSCAFG00000014548

p.E2759G

30

FRAS1

ENSCAFG00000008752

p.I1313fs

32

FREM2

ENSCAFG00000006019

p.D1252Y

25

GGNBP2

ENSCAFG00000017839

NA

9

LAMA1

ENSCAFG00000018597

p.S3027F

7

MLEC

ENSCAFG00000010408

p.E109K

26

MTX2

ENSCAFG00000013416

p.L157_Y159del

36

NUGGC

ENSCAFG00000008347

p.R651fs

25

OPCML

ENSCAFG00000009842

p.N40H

5

PDGFD

ENSCAFG00000032342

p.S265T

5

PTPN11

ENSCAFG00000008894

p.E76K

26

RELN

ENSCAFG00000025345

p.I819M

18

RIPK1

ENSCAFG00000009321

p.L659fs

35

SLC6A13

ENSCAFG00000015769

p.R413H

27

SMARCAL1

ENSCAFG00000014421

p.R652C

37