Table 2 Effects of IAH on the related indexes according to the nine orthogonal test subgroups (Mean ± SD).
From: Optimizing intra-arterial hypothermia scheme for acute ischemic stroke in an MCAO/R rat model
Indexes | H1 (4 °C, 1/3 RICA, 30 min, 7.5 ml) | H2 (4 °C, 1/2 RICA, 20 min, 7.5 ml) | H3 (4 °C, 2/3 RICA, 10 min, 5.0 ml) | H4(10 °C, 2/3RICA, 20 min, 10.0 ml) | H5(10 °C,1/2 RICA, 30 min, 11.3 ml) | H6(10 °C, 1/3RICA, 10 min, 2.5 ml) | H7(15 °C,1/3 RICA, 20 min, 5.0 ml) | H8(15 °C,1/2RICA, 10 min, 11.3 ml) | H9(15 °C,2/3 RICA, 30 min,15.0 ml) |
|---|---|---|---|---|---|---|---|---|---|
The Tb-related indexes | |||||||||
Time of Tb-35 °C (min, n = 7) | 6.14 ± 0.38** | 4.71 ± 0.49** | 3.43 ± 0.53R | 4.86 ± 0.38** | 5.71 ± 0.49** | 7.43 ± 0.53** | 7.71 ± 0.49** | 5.86 ± 0.38** | 4.71 ± 0.49** |
Tb-min ( °C, n = 7) | 31.25 ± 0.08** | 31.78 ± 0.09** | 32.56 ± 0.16** | 30.45 ± 0.09** | 30.05 ± 0.05** | 34.45 ± 0.13** | 33.20 ± 0.06** | 33.85 ± 0.08** | 29.65 ± 0.06R |
Time of TH (min, n = 7) | 26.29 ± 0.49** | 17.57 ± 0.53** | 7.71 ± 0.49** | 18.57 ± 0.53** | 27.71 ± 0.49** | 3.29 ± 0.49** | 13.43 ± 0.53** | 4.43 ± 0.53** | 28.71 ± 0.49R |
Rewarming time (min, n = 7) | 3.86 ± 0.38** | 3.43 ± 0.53** | 2.86 ± 0.38** | 4.43 ± 0.53NS | 4.57 ± 0.53NS | 1.71 ± 0.49** | 2.57 ± 0.53** | 2.14 ± 0.38** | 4.86 ± 0.38R |
The outcome indexes | |||||||||
Infarction volume (%, n = 7) | 27.05 ± 1.73** | 23.96 ± 2.54NS | 24.14 ± 1.68NS | 25.84 ± 1.42* | 28.76 ± 1.64** | 33.42 ± 2.51** | 32.78 ± 2.02** | 31.86 ± 1.86** | 23.58 ± 2.10R |
Cerebral water content (%, n = 7) | 81.51 ± 0.21** | 80.42 ± 0.18NS | 80.53 ± 0.17* | 80.77 ± 0.14** | 81.91 ± 0.18** | 82.73 ± 0.20** | 82.61 ± 0.17** | 82.51 ± 0.18** | 80.32 ± 0.18R |
mNSS ( n = 7) | 8.43 ± 1.40NS | 7.86 ± 1.35NS | 7.71 ± 1.50NS | 8.00 ± 1.41NS | 8.43 ± 1.62NS | 10.86 ± 2.12** | 9.86 ± 1.86** | 10.00 ± 1.63** | 7.57 ± 1.72R |
