Table 1 Demographical and biochemical characteristics of study cohorts.
From: Circulating miRNA expression in long-standing type 1 diabetes mellitus
Discovery cohort | Validation cohort | |||
|---|---|---|---|---|
Control | Type 1 diabetes | Control | Type 1 diabetes | |
N | 10 | 20 | 21 | 34 |
Gender (% male) | 50 | 65 | 29 | 62 |
Age (years) | 34.6 ± 3.0 | 33.2 ± 2.3 | 28.9 ± 2.1 | 34.4 ± 2.2 |
Age at onset (years) | – | 16.6 ± 3.1 | – | 19.7 ± 2.0 |
Disease duration (years) | – | 16.0 ± 2.3 | – | 14.7 ± 1.4 |
Anthropometric | ||||
BMI (kg/m2) | 24.0 ± 0.8 | 24.9 ± 0.7 | 22.2 ± 0.4 | 24.1 ± 0.6** |
Fat (%) | 25.5 ± 2.4 | 23.3 ± 2.2 | 25.6 ± 1.8 | 23.6 ± 1.4 |
Waist | 80.1 ± 2.9 | 84.6 ± 2.4 | 75.0 ± 2.0 | 84.5 ± 2.4* |
Biochemical | ||||
Glucose (mg/dL) | 82.6 ± 1.9 | 187.0 ± 15.8*** | 80.6 ± 1.6 | 200.0 ± 14.4*** |
HbA1c1 (%) | 5.0 ± 0.1 | 7.0 ± 0.2*** | 4.9 ± 0.1 | 7.7 ± 0.2*** |
C Peptide (ng/mL) | – | 0.22 ± 0.05 | – | 0.14 ± 0.07 |
Total cholesterol (mg/dL) | 182.0 ± 13.6 | 178.0 ± 6.8 | 169.8 ± 5.9 | 175.4 ± 5.3 |
HDL (mg/dL) | 62.0 ± 5.3 | 59.7 ± 1.8 | 65.1 ± 2.9 | 63.6 ± 2.7 |
Triglycerides (mg/dL) | 69.3 ± 6.5 | 80.1 ± 6.6 | 66.9 ± 4.8 | 82.8 ± 7.8 |
LDL (mg/dL) | 106.0 ± 12.1 | 102.0 ± 6.0 | 91.3 ± 5.0 | 96.2 ± 4.5 |
TSH | 2.4 ± 0.2 | 2.5 ± 0.3 | 2.3 ± 0.2 | 2.3 ± 0.2 |
HLA | ||||
HLADR3 (%) | 0 | 100 | 28.6 | 58.8 |
HLADR4 (%) | 0 | 85 | 23.8 | 50.0 |
HLADQ2 (%) | 0 | 100 | 28.6 | 58.8 |
HLADR8 (%) | 0 | 80 | 23.8 | 47.1 |
