Figure 3
From: Streptozotocin induces renal proximal tubular injury through p53 signaling activation
Dose-dependent tubular injury by STZ in vivo. (a) Decreases in blood glucose levels in mice treated with 200 mg/kg of STZ. (b) Plasma insulin levels were higher in high dose of STZ-treatment groups. (c) BUN levels did not differ among experimental groups. (d) Microscopic images of kidney tissue with PAS staining and immunostaining for megalin showed increases in the tubules with the loss of the brush border and decreases in megalin expression in STZ-treated mice. (e) qPCR of RNA from kidney tissue for the representative markers of injured and healthy tubules (apical membrane sodium transporters). In all groups, data are means ± SEM. Statistical analyses were performed using Dunnett's post hoc test was used for multiple comparisons. N = 5 to 7 mice per group. * p < 0.05, Bar = 50 μm in (c).
