Figure 7
From: Streptozotocin induces renal proximal tubular injury through p53 signaling activation
Pharmacological inhibition of p53 signaling and SGLT2 ameliorated STZ-induced tubular injury in vivo. (a) Microscopic images of kidney tissue stained with PAS and immunostained for megalin. (b) qPCR of RNA from kidney tissue for the representative markers of injured and healthy tubules (apical membrane sodium transporters). In all groups, data are the means ± SEM. Statistical analyses were performed using Dunnett's post hoc test was used for multiple comparisons. N = 5 to 11 mice per group. * p < 0.05, Bar = 50 μm in images of PAS staining and 100 μm in images of immunostaining for megalin in (c).
