Table 3 Associations between ferritin and different clinical outcomes in three models.

From: The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

Exposure

Crude model

Model I

Model II

OR (95% CI), P-value

OR(95% CI), P-value

OR (95% CI), P-value

28-day mortality

 Ferritin (per 1000 ng/ml increment)

1.13 (1.08, 1.18) < 0.0001

1.14 (1.09, 1.20) < 0.0001

1.13 (1.07, 1.19) < 0.0001

 Ferritin (ng/ml)quartiles

  Q1

Ref

Ref

Ref

  Q2

0.94 (0.66, 1.33) 0.7328

0.94 (0.67, 1.34) 0.7500

1.00 (0.69, 1.44) 0.9971

  Q3

1.35 (0.97, 1.88) 0.0721

1.38 (0.99, 1.93) 0.0559

1.40 (0.98, 2.01) 0.0640

  Q4

2.22 (1.63, 3.04) < 0.0001

2.40 (1.75, 3.30) < 0.0001

2.16 (1.53, 3.07) < 0.0001

 P for trend

 < 0.0001

 < 0.0001

 < 0.0001

90-day mortality

 Ferritin (per 1000 ng/ml increment)

1.14 (1.09, 1.19) < 0.0001

1.16 (1.11, 1.21) < 0.0001

1.15 (1.09, 1.21) < 0.0001

 Ferritin (ng/ml)quartiles

  Q1

Ref

Ref

Ref

  Q2

1.04 (0.77, 1.40) 0.8049

1.05 (0.78, 1.42) 0.7461

1.16 (0.84, 1.59) 0.3717

  Q3

1.39 (1.04, 1.86) 0.0254

1.45 (1.08, 1.94) 0.0132

1.54 (1.12, 2.12) 0.0076

  Q4

2.22 (1.68, 2.94) < 0.0001

2.40 (1.80, 3.19) < 0.0001

2.31 (1.69, 3.17) < 0.0001

 P for trend

 < 0.0001

 < 0.0001

 < 0.0001

180-day mortality

 Ferritin (per 1000 ng/ml increment)

1.15 (1.10, 1.20) < 0.0001

1.17 (1.11, 1.22) < 0.0001

1.16 (1.10, 1.22) < 0.0001

 Ferritin (ng/ml)quartiles

  Q1

Ref

Ref

Ref

  Q2

1.01 (0.76, 1.36) 0.9259

1.02 (0.76, 1.37) 0.8765

1.13 (0.83, 1.54) 0.4503

  Q3

1.44 (1.09, 1.91) 0.0114

1.49 (1.12, 1.98) 0.0062

1.58 (1.16, 2.15) 0.0038

  Q4

2.23 (1.69, 2.93) < 0.0001

2.39 (1.81, 3.16) < 0.0001

2.30 (1.69, 3.14) < 0.0001

 P for trend

 < 0.0001

 < 0.0001

 < 0.0001

1-year mortality

 Ferritin (per 1000 ng/ml increment)

1.15 (1.10, 1.21) < 0.0001

1.17 (1.11, 1.23) < 0.0001

1.17 (1.10, 1.23) < 0.0001

 Ferritin (ng/ml)quartiles

  Q1

Ref

Ref

Ref

  Q2

1.02 (0.77, 1.37) 0.8682

1.03 (0.77, 1.38) 0.8304

1.13 (0.83, 1.53) 0.4388

  Q3

1.43 (1.08, 1.88) 0.0125

1.47 (1.11, 1.94) 0.0079

1.53 (1.13, 2.08) 0.0063

  Q4

2.17 (1.66, 2.85) < 0.0001

2.31 (1.75, 3.04) < 0.0001

2.19 (1.61, 2.97) < 0.0001

P for trend

 < 0.0001

 < 0.0001

 < 0.0001

  1. Crude model adjusted for: None;
  2. Model I adjusted for: age; gender;
  3. Model II adjusted for: age; gender; ALT; AG; total calcium; creatinine; hematocrit; hemoglobin; PLT; PT; TT; RDW; RBC; urea nitrogen; renal disease; APAHCEII; SOFA.
  4. ALT, alanine aminotransferase; PLT, platelet; RDW, red blood cell distribution width; RBC, red blood cells; PT, prothrombin time; TT, thrombin time; AG, anion gap; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; OR, odds ratio; CI, confidential interval.
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