Table 4 The threshold effect for analysis between ferritin and clinical outcomes.

From: The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

 

Number (%)

OR (95% CI), P-value

28-day mortality

 Model A: The linear model

1947 (100%)

1.13 (1.07, 1.19) < 0.0001

 Model B: Two-segment non-linear model

  

 The turning point of ferritin (ng/ml)

  

   ≤ 2340( slope 1)

1762 (90.50%)

1.54 (1.29, 1.85) < 0.0001

   > 2340( slope 2)

185 (9.50%)

1.04 (0.97, 1.11) 0.2873

  Slope 2 to slope 1

 

0.67 (0.54, 0.84) 0.0004

  Predicted at 2340

 

− 0.68 (− 0.95, − 0.41)

 P for the log-likelihood ratio test

 

 < 0.001

90-day mortality

 Model A: The linear model

1947 (100%)

1.15 (1.09, 1.21) < 0.0001

 Model B: Two-segment non-linear model

  

 The turning point of ferritin(ng/ml)

  

   ≤ 2250( slope 1)

1754 (90.09%)

1.54 (1.30, 1.83) < 0.0001

   > 2250( slope 2)

193 (9.91%)

1.06 (0.99, 1.13) 0.0967

  Slope 2 to slope 1

 

0.69 (0.56, 0.84) 0.0004

  Predicted at 2250

 

− 0.31 (− 0.56, − 0.06)

 P for the log-likelihood ratio test

 

 < 0.001

180-day mortality

 Model A: The linear model

1947 (100%)

1.16 (1.10, 1.22) < 0.0001

 Model B: Two-segment non-linear model

  

 The turning point of ferritin(ng/ml)

  

   ≤ 2280( slope 1)

1755 (90.14%)

1.56 (1.32, 1.84) < 0.0001

   > 2280( slope 2)

192 (9.86%)

1.06 (1.00, 1.14) 0.0695

  Slope 2 to slope 1

 

0.68 (0.56, 0.84) 0.0003

  Predicted at

 

− 0.18 (− 0.43, 0.06)

 P for the log-likelihood ratio test

 

 < 0.001

1-year mortality

 Model A: The linear model

1947 (100%)

1.17 (1.10, 1.23) < 0.0001

 Model B: Two-segment non-linear model

  

 The turning point of ferritin(ng/ml)

  

   ≤ 2300(slope 1)

1756 (90.19%)

1.50 (1.27, 1.76) < 0.0001

   > 2300(slope 2)

191 (9.81%)

1.08 (1.01, 1.16) 0.0281

 Slope 2 to slope 1

 

0.72 (0.59, 0.88) 0.0017

 Predicted at 2300

 

− 0.15 (− 0.40, 0.09)

 P for the log-likelihood ratio test

 

0.002

  1. Model A and B adjusted for: age; gender; ALT; AG; total calcium; creatinine; hematocrit; hemoglobin; PLT; PT; TT; RDW; RBC; urea nitrogen; renal disease; APAHCEII; SOFA.
  2. ALT, alanine aminotransferase; PLT, platelet; RDW, red blood cell distribution width; RBC, red blood cells, PT, prothrombin time; TT, thrombin time; AG, anion gap; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; OR, odds ratio; CI, confidential interval.