Table 3 IC50 and Hill coefficient (p) values determined for SARS-CoV-2 nsp14 N7-MTase using the Py-FLINT assay. For inhibition curves see Supplementary Information Fig. S2.

From: Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

SARS-CoV-2 nsp14

R:

IC50 (µM)

p

Ebselen

0.35 ± 0.03

2.74 ± 0.47

3

0.35 ± 0.02

3.12 ± 0.47

7

0.35 ± 0.02

4.08 ± 1.33

10

3.08 ± 0.46

1.73 ± 0.35

16

0.42 ± 0.04

2.36 ± 0.32

17

3.83 ± 0.35

2.15 ± 0.28

  1. Significant values are in bold.
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