Table 1 Patients’ characteristics.

From: Genomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer

 

N = 93

Age (years, median, range)

54 (20–70)

Menstruation status

 Premenopausal

32 (34.4%)

 Postmenopausal

60 (64.5%)

 Unknown

1 (1.1%)

HR status

 HR ( +)

53 (57.0%)

 HR (−)

37 (39.8%)

 Unknown

3 (3.2%)

De novo stage IV

29 (31.2%)

No. of prior chemotherapy regimens at metastatic setting* (median, range)

4 (2–11)

 1–3

35 (38.0%)

 > 3

57 (62.0%)

 Unknown

1 (1.1%)

No. of prior anti-HER2 therapy at metastatic setting** (median, range)

3 (0–8)

 1–3

71 (76.3%)

 > 3

22 (23.7%)

Prior anti-HER2 agents

 Trastuzumab

90 (96.8%)

 Pertuzumab

39 (41.9%)

 Trastuzumab emtansine (T-DM1)

90 (96.8%)

 Lapatinib

70 (75.3%)

 Trastuzumab deruxtecan (T-Dxd)

9 (9.7%)

  1. HR hormone receptor, No. number.
  2. *Number of all administered chemotherapies regardless of anti-HER2 drugs in a metastatic setting.
  3. **Number of anti-HER2 based treatments in a metastatic setting.