Table 1 A-priori hypotheses about differences in functional connectivity between pre-defined regions of interest in generalized anxiety disorder relative to healthy comparisons.

Region A	Region B	Hypothesis on FC
Posterior cingulate cortex	Ventromedial prefrontal cortex	Decreased¹²
Posterior cingulate cortex	Dorsomedial prefrontal cortex	Decreased¹²
Anterior insula	Dorsal anterior cingulate cortex	Decreased³⁹
Dorsolateral prefrontal cortex	Amygdala	Increased^13,40
Anterior insula	Ventromedial prefrontal cortex	Decreased²⁹
Posterior-mid insula	Ventromedial prefrontal cortex	Decreased²⁹
Amygdala	Dorsal anterior cingulate cortex	Decreased^15,41
Amygdala	Temporal pole	Increased¹⁶
Amygdala	Ventromedial prefrontal cortex	Increased^42,43
Amygdala	Anterior insula	Increased^44,45
Amygdala	Posterior/mid insula	Increased^44,45

Bilateral regions of interest (ROIs) were defined according to the label groupings from the Brainnetome atlas³⁸: Posterior cingulate cortex, ventromedial prefrontal cortex, dorsomedial prefrontal cortex, dorsal anterior cingulate cortex, anterior insula (encompassing the agranular insula in entirety), posterior-mid insula (encompassing the granular and dysgranular insula in entirety), amygdala, dorsolateral prefrontal cortex, temporal pole. The corresponding IDs from the Brainnetome atlas defining each ROI are listed in the Supplement. References to previous literature our hypotheses were derived from are denoted in superscript numbers.

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