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Figure 1

From: Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1

Figure 1

Chemical-induced hypoxia prolongs action potential duration in rat neonatal cardiomyocytes. (A) Representative action potential traces of cardiomyocytes subjected to normoxia or chemical hypoxia and treated with a vehicle. APD at 30% (B), 50% (C), and 90% (D) of repolarization corrected by the beat rate (n = 31–41). The points represent individual measurements, and the bars represent the mean ± SEM. The significance of differences was determined using the unpaired t-test or Mann–Whitney test. ***P < 0.001 versus normoxia.

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