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Figure 2

From: Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1

Figure 2

Chemical-induced hypoxia prolongs action potential duration in cardiomyocytes derived from human iPSCs. (A) Representative action potential traces of cardiomyocytes subjected to normoxia or chemical hypoxia and treated with a vehicle. Action potentials were evoked by pulses at 1 Hz. APD at 30% (B), 50% (C), and 90% (D) of repolarization (n = 7–12). The points represent individual measurements, and the bars represent the mean ± SEM. The significance of differences was determined using the unpaired t-test. *P < 0.05 and **P < 0.01 versus normoxia.

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