Figure 3 | Scientific Reports

Figure 3

From: Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1

Figure 3

Empagliflozin reduced the action potential duration in rat neonatal cardiomyocytes under normoxic and hypoxic conditions. Action potential recordings in cardiomyocytes subjected to normoxia or chemical hypoxia and treated with vehicle or EMPA were obtained using the intracellular microelectrode technique. (A) Representative single-cell action potential traces. APD at 30% (B), 50% (C), and 90% (D) of repolarization corrected by the beat rate. (E) RMP. (F) APA. The points represent individual measurements, and the bars are the mean ± SEM (n = 30–41). The significance of differences was determined using the unpaired t-test or Mann–Whitney test. *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle.

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