Table 2 Comparison of Outcomes associated with pain VAS between IA PN and IA HMWHA groups.

From: A randomized controlled trial for comparing efficacy and safety between intraarticular polynucleotide and hyaluronic acid for knee osteoarthritis treatment

 

IA PN (n = 22)

IA HMWHA (n = 27)

p-value

Weight bearing VAS change rate

 Week 8—baseline (%)

− 33.9 ± 35.8

− 36.0 ± 40.2

0.847

 Week 16—baseline (%)

− 54.0 ± 38.1

− 42.8 ± 35.8

0.296

At rest VAS change rate

 Week 8—baseline (%)

− 38.4 ± 73.7

− 26.6 ± 67.9

0.610

 Week 16—baseline (%)

− 63.6 ± 76.3

− 60.5 ± 55.8

0.890

Walking VAS change rate

 Week 8—baseline (%)

− 28.6 ± 60.9

− 20.7 ± 55.0

0.639

 Week 16—baseline (%)

− 41.2 ± 45.3

− 28.3 ± 51.2

0.374

Weight bearing VAS change (100 mm)

 Week 8—baseline (mm)

− 16.5 ± 16.5

− 19.3 ± 22.5

0.624

 p-value (within)

0.000*

0.000*

 

 Week 16—baseline (mm)

− 27.4 ± 17.5

− 22.8 ± 19.8

 

 p-value (within)

0.000*

0.000*

 

At rest VAS change rate (100 mm)

 Week 8—baseline (mm)

− 11.1 ± 22.1

− 8.7 ± 22.8

0.713

 p-value (within)

0.028*

0.057

 

 Week 16—baseline (mm)

− 16.7 ± 21.1

− 14.2 ± 23.0

0.709

 p-value (within)

0.002*

0.004*

 

Walking VAS change rate (100 mm)

 Week 8—baseline (mm)

− 16.3 ± 17.6

− 14.1 ± 25.1

0.729

 p-value (within)

0.000*

0.007*

 

Week 16—baseline (mm)

− 21.4 ± 17.7

− 17.5 ± 24.2

0.538

 p-value (within)

0.000*

0.001*

 
  1. IA PN Intraarticular polynucleotide, IA HMWHA Intraarticular high molecular weight hyaluronic acid.
  2. p-value (within) : paired t-test, p-value : two sample t-test, *statistical significance (+).
Back to article page