Table 1 Synergistic effects of TNF-α and IFNg on barrier function evaluated by TEER.

From: A platform to reproducibly evaluate human colon permeability and damage

Donor A, 72H: IFNγ EC50

TNFα [ng/mL]

0

0.14

0.41

1.2

3.7

11

33

100

IFNγ EC50 [U/mL]

Unstable

18

59

4.5

16

0.96

0.21

0.33

R2

0.554

0.782

0.937

0.905

0.996

0.997

0.981

1

Donor A, 72 H: TNFα EC50

IFNγ [U/mL]

0

1.6

8

40

200

1000

TNFα EC50 [ng/mL]

0.14

10

1.7

0.03

0.12

0.18

R2

0.430

0.941

0.845

0.676

0.801

0.902

  1. Non-linear three parameter fit was used to calculate EC50 values, shown with R2 values which correspond to Fig. 3C plots. “Unstable” was designated by Prism software and indicates that no inflection point was defined.
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