Table 3 Multivariable Cox regression analysis of long-term outcomes according to the characteristics of ESUS subtype.
From: Prognostic value of central blood pressure on the outcomes of embolic stroke of undetermined source
MACE* | Stroke recurrence* | All-cause mortality* | ||||
|---|---|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Arteriogenic embolism (n = 155) | ||||||
Central SBP ≥ 130 mmHg | 1.131 (0.519‒2.464) | 0.757 | 0.920 (0.328‒2.582) | 0.874 | 1.107 (0.324‒3.782) | 0.872 |
Central DBP ≥ 90 mmHg | 1.739 (0.757‒3.991) | 0.192 | 1.307 (0.428‒3.987) | 0.638 | 1.928 (0.482‒7.719) | 0.353 |
Central PP > 50 mmHg | 0.935 (0.412‒2.118) | 0.871 | 0.894 (0.307‒2.605) | 0.838 | 0.677 (0.169‒2.714) | 0.582 |
AP > 13 mmHg | 0.502 (0.232‒1.088) | 0.081 | 0.738 (0.273‒1.996) | 0.550 | 0.239 (0.057‒0.992) | 0.049 |
AIx > 25% | 1.096 (0.489‒2.459) | 0.823 | 0.963 (0.345‒2.688) | 0.943 | 1.170 (0.289‒4.738) | 0.826 |
Minor cardioembolism (n = 200) | ||||||
Central SBP ≥ 130 mmHg | 1.258 (0.472‒3.350) | 0.646 | 3.324 (0.832‒13.284) | 0.089 | 0.982 (0.185‒5.212) | 0.983 |
Central DBP ≥ 90 mmHg | 1.280 (0.461‒3.549) | 0.636 | 1.478 (0.403‒5.422) | 0.556 | 0.487 (0.051‒4.617) | 0.531 |
Central PP > 50 mmHg | 0.587 (0.185‒1.867) | 0.367 | 0.866 (0.207‒3.634) | 0.845 | 1.149 (0.188‒7.031) | 0.880 |
AP > 13 mmHg | 1.525 (0.550‒4.225) | 0.417 | 1.948 (0.530‒7.158) | 0.315 | 3.950 (0.481‒32.448) | 0.201 |
AIx > 25% | 1.419 (0.509‒3.956) | 0.503 | 1.797 (0.479‒6.737) | 0.385 | 7.367 (0.612‒88.706) | 0.116 |
Two more causes (n = 180) | ||||||
Central SBP ≥ 130 mmHg | 1.077 (0.475‒2.439) | 0.859 | 1.448 (0.524‒3.999) | 0.475 | 1.520 (0.324‒7.122) | 0.595 |
Central DBP ≥ 90 mmHg | 2.264 (0.877‒5.845) | 0.091 | 2.292 (0.745‒7.056) | 0.148 | 1.045 (0.117‒9.306) | 0.969 |
Central PP > 50 mmHg | 1.291 (0.544‒3.066) | 0.562 | 1.268 (0.439‒3.665) | 0.661 | 2.825 (0.514‒15.517) | 0.232 |
AP > 13 mmHg | 0.824 (0.360‒1.888) | 0.648 | 0.862 (0.310‒2.393) | 0.775 | 2.163 (0.406‒11.538) | 0.366 |
AIx > 25% | 0.985 (0.428‒2.375) | 0.985 | 0.441 (0.147‒1.322) | 0.144 | 17.928 (1.760‒182.668) | 0.015 |
No cause (n = 211) | ||||||
Central SBP ≥ 130 mmHg | 2.690 (1.100‒6.578) | 0.030 | 5.126 (1.309‒20.077) | 0.019 | 1.274 (0.299‒5.429) | 0.743 |
Central DBP ≥ 90 mmHg | 0.909 (0.336‒2.460) | 0.851 | 1.149 (0.309‒4.277) | 0.836 | 0.794 (0.137‒4.616) | 0.798 |
Central PP > 50 mmHg | 6.943 (2.560‒18.834) | < 0.001 | 9.669 (2.262‒41.319) | 0.002 | 4.557 (0.859‒24.168) | 0.075 |
AP > 13 mmHg | 4.929 (1.869‒13.001) | 0.001 | 7.797 (1.826‒33.296) | 0.006 | 6.539 (1.151‒37.144) | 0.034 |
AIx > 25% | 3.952 (1.638‒9.534) | 0.002 | 2.614 (0.852‒8.023) | 0.093 | 9.744 (1.561‒60.813) | 0.015 |
