Table 1 Baseline characteristics at admission and hospital mortality in the groups with uncomplicated malaria (UM) and severe malaria (SM).
Total (n = 278) | UM (n = 134) | SM (n = 144) | P | LSM (n = 76) | VSM (n = 68) | P | |
|---|---|---|---|---|---|---|---|
Age, years, median [IQR] | 42 [32–52] | 38 [29–47] | 45 [35–57] | < 0.01 | 43 [29–56] | 48 [38–57] | 0.03 |
Male, n (%) | 193 (69.4) | 97 (72.4) | 96 (66.7) | 0.30 | 46 (60.5) | 50 (73.5) | 0.10 |
Black African n (%) | 148 (53.2) | 79(59.0) | 69 (47.9) | 0.08 | 50 (65.8) | 19 (27.9) | < 0.01 |
Lives in an endemic area, n (%) | 45 (16.4) | 25 (18.9) | 20 (14.1) | 0.28 | 11 (14.5) | 9 (13.6) | 0.88 |
African country source, n (%) | 266 (96.7) | 130 (97.7) | 136 (95.8) | 0.50 | 74 (97.4) | 62 (93.9) | 0.41 |
Antimalarial chemoprophylaxis, n (%) | 81 (29.3) | 40 (29.9) | 41 (28.9) | 0.86 | 22 (28.9) | 19 (28.8) | 0.98 |
Immune suppression, n (%) | 23 (8.4) | 7 (5.3) | 16 (11.3) | 0.07 | 6 (8.1) | 10 (14.7) | 0.21 |
At least one comorbidity, n (%) | 31 (11.3) | 8 (6.0) | 23 (16.3) | < 0.01 | 9 (12.3) | 14 (20.6) | 0.18 |
Time from symptom onset to hospital admission, days, median [IQR] | 4 [2–6] | 3 [2–6] | 4 [3–6.5] | < 0.01 | 4.5 [3.0–6.0] | 4.0 [2.5–7.0] | 0.80 |
Characteristics at admission | |||||||
Number of WHO criteria on day 1, median [IQR] | 1 [0–2] | 0 [0–0] | 2 [1–3] | – | 1 [1–2] | 3 [2–5] | < 0.01 |
Parasitemia on day 1, %, median [IQR] | 2.5 [0.3–9.0] | 0.5 [0.1–2.1] | 8.0 [3.8–15.0] | < 0.01 | 8.0 [4.0–14.0] | 9.5 [3.3–20.0] | 0.18 |
pfHRP2 on day 1 (ng/mL), median, [IQR] | 263 [40–983] | 60.7 [12–261] | 834.4 [304–2099] | < 0.01 | 693 [193–1422] | 1110 [475–3402] | 0.01 |
Outcome | |||||||
Bacterial coinfection < 48 h, n (%) | 11 (4.0) | 1 (0.7) | 10 (6.9) | < 0.01 | 2 (2.6) | 8 (11.8) | 0.04 |
Nosocomial infection, n (%) | 23 (8.3) | 2 (1.5) | 21 (14.6) | < 0.01 | 5 (6.6) | 16 (23.5) | < 0.01 |
Death, n (%) | 8 (5.2) | 0 | 8 (5.2) | NA | |||
