Table 3 Multivariable multinomial random-effects logistic regression model on the predictors of positive and negative symptom trajectories in siblings.
Predictors | Positive symptom trajectories (Ref = Low) | Negative symptom trajectories (Ref = Low) | ||||||
|---|---|---|---|---|---|---|---|---|
Moderate | High (high and high-decreased) | Moderate | High (increased and decreased) | |||||
OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
Schizophrenia polygenic risk scores | ||||||||
PRSPT=0.05 | 1.01 (0.95; 1.08) | 0.66 | 1.08 (1.00; 1.17) | 0.05 | 1.00 (0.93; 1.07) | 0.92 | 1.01 (0.91; 1.12) | 0.84 |
Demographic and clinical characteristics | ||||||||
Age | 0.99 (0.96; 1.02) | 0.50 | 0.98 (0.93; 1.02) | 0.30 | ||||
Gender, female | 1.46 (0.82; 2.58) | 0.20 | 0.66 (0.32; 1.34) | 0.25 | ||||
Marital status, married | 0.82 (0.45; 1.49) | 0.51 | 0.73 (0.30; 1.78) | 0.49 | ||||
Years of education (full-time) | 0.96 (0.89; 1.03) | 0.24 | 0.96 (0.88; 1.05) | 0.34 | ||||
Premorbid adjustment | 1.41 (0.89; 2.24) | 0.14 | 1.09 (0.63; 1.89) | 0.75 | 2.02 (1.11; 3.68) | 0.02 | 4.28 (2.05; 8.95) | 0.0001 |
Premorbid IQ | 1.01 (0.99; 1.03) | 0.32 | 1.00 (0.97; 1.02) | 0.75 | ||||
Psychotic-like experiences (distress) | ||||||||
Positive symptoms | 0.70 (0.34; 1.43) | 0.33 | 1.16 (0.51; 2.65) | 0.72 | 1.62 (0.70; 3.78) | 0.26 | 3.00 (1.04; 8.68) | 0.04 |
Negative symptoms | 2.22 (0.91; 5.43) | 0.08 | 2.41 (0.85; 6.81) | 0.10 | 1.34 (0.52; 3.47) | 0.55 | 2.45 (0.66; 9.05) | 0.18 |
Depressive symptoms | 0.86 (0.43; 1.74) | 0.68 | 2.67 (1.13; 6.32) | 0.03 | 2.05 (0.89; 4.70) | 0.09 | 1.89 (0.59; 6.06) | 0.28 |
Quality of life and functioning | ||||||||
Health-related quality of life | 0.58 (0.28; 1.24) | 0.16 | 0.27 (0.11; 0.68) | 0.01 | 0.16 (0.05; 0.49) | 0.0015 | 0.06 (0.01; 0.21) | < 0.0001 |
