Table 2 The distribution of healthcare service utilization by year.

From: Current treatments for endometriosis in South Korea: an analysis of nationwide data from 2010 to 2019

 

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

RR (crude)

RR (adjusted)

Outpatient visits

2.39 (2.20)

2.48 (2.24)

2.75 (2.36)

3.08 (3.56)

2.97 (2.91)

2.89 (2.91)

2.95 (3.71)

2.86 (2.96)

2.97 (2.38)

2.82 (2.33)

1.01 (1.01 to 1.02)***

1.01 (1.01 to 1.02)***

Admission rate

15.6

17.7

18.0

14.1

15.9

14.7

17.1

13.1

13.6

12.7

0.97 (0.95 to 0.99)**

0.97 (0.95 to 0.99)**

Surgery rate

16.3

18.2

19.4

16.1

17.7

16.1

17.6

13.8

14.0

12.7

0.97 (0.95 to 0.98)***

0.97 (0.95 to 0.98)***

 Laparoscopy

9.3

11.1

11.1

10.8

15.3

14.0

15.4

12.0

11.9

10.1

1.01 (0.99 to 1.03)

1.01 (0.99 to 1.03)

 Surgery type

  Extirpation of benign adnexal tumor

9.3

8.9

10.0

10.0

11.4

9.6

11.4

9.4

9.4

8.4

0.99 (0.97 to 1.02)

0.99 (0.97 to 1.02)

  Pelviscopic fulguration

1.2

1.4

0.8

1.5

2.0

1.8

1.5

1.2

1.1

0.5

0.96 (0.89 to 1.03)

0.96 (0.90 to 1.03)

Prescription rate

 Hormone therapy

41.4

38.0

35.5

40.0

45.9

45.8

46.0

46.7

50.4

50.0

1.03 (1.02 to 1.05)***

1.03 (1.02 to 1.05)***

  Estrogen or progesterone

15.9

14.2

12.0

23.2

34.2

34.0

35.5

36.7

40.2

41.4

1.13 (1.11 to 1.14)***

1.13 (1.11 to 1.14)***

   Dienogest

0.0

0.0

0.0

12.1

27.6

27.0

28.7

30.8

34.8

36.0

1.27 (1.25 to 1.30)***

1.28 (1.25 to 1.30)***

   Tibolone

4.3

4.4

3.8

4.4

3.5

2.8

2.3

2.5

2.8

2.6

0.93 (0.89 to 0.97)***

0.93 (0.89 to 0.97)***

  GnRH analogues

33.6

31.5

31.3

26.7

20.3

19.1

17.2

16.3

18.3

16.4

0.91 (0.90 to 0.93)***

0.91 (0.90 to 0.93)***

   Leuprorelin

23.1

22.5

23.8

20.3

14.5

15.3

13.7

13.6

15.2

14.3

0.94 (0.92 to 0.95)***

0.94 (0.92 to 0.95)***

   Goserelin

5.8

5.5

5.7

4.4

3.1

2.2

1.5

1.5

2.0

0.9

0.82 (0.78 to 0.86)***

0.82 (0.78 to 0.86)***

  NSAIDs

26.6

28.5

26.9

17.3

13.4

10.7

12.5

11.1

10.7

12.8

0.89 (0.87 to 0.91)***

0.89 (0.87 to 0.91)***

Prescription days

 Hormone therapy

24.1 (52.1)

29.2 (59.2)

23.9 (50.6)

47.5 (84.4)

76.9 (111.4)

63.1 (97.4)

71.4 (117.2)

75.7 (113)

78.4 (119)

73.8 (112.2)

1.11 (1.11 to 1.11)***

1.11 (1.11 to 1.12)***

  Estrogen or progesterone

52 (72.1)

66.6 (79.5)

62.5 (71.2)

77.7 (99.3)

100.7 (119.3)

83 (105.4)

90.6 (126.9)

91.6 (118.7)

95.6 (126.5)

87.6 (118.2)

1.03 (1.03 to 1.04)***

1.04 (1.03 to 1.04)***

   Dienogest

77.1 (106.6)

106.1 (124.2)

81.7 (107.5)

93 (129.1)

93.4 (118.3)

92.5 (123.6)

86 (117.9)

0.99 (0.99 to 0.99)***

0.99 (0.99 to 0.99)***

   Tibolone

53.3 (41.2)

88.9 (76.2)

87.1 (70)

116.1 (97.3)

85.5 (79.5)

98.3 (99.8)

92 (85.3)

102.3 (102.7)

108.4 (102.7)

100.5 (102)

1.04 (1.03 to 1.04)***

1.04 (1.04 to 1.04)***

  GnRH analogues

3 (1.7)

3.1 (1.7)

3.1 (1.8)

3.4 (1.7)

3.1 (1.7)

3.1 (1.8)

3.1 (1.6)

2.9 (1.5)

3.1 (1.9)

3 (1.7)

1.00 (0.99 to 1.01)

1.00 (0.99 to 1.01)

   Leuprorelin

3 (1.7)

2.9 (1.7)

3.1 (1.8)

3.4 (1.7)

3.1 (1.7)

3.1 (1.9)

3 (1.6)

2.8 (1.5)

3 (1.6)

3 (1.7)

1.00 (0.99 to 1.01)

1.00 (0.99 to 1.01)

   Goserelin

2.4 (1.7)

3.3 (1.7)

2.7 (1.7)

3.2 (1.9)

3.2 (1.5)

2.8 (1.5)

3.4 (1.6)

3.4 (2)

2.9 (1.9)

3.4 (1.6)

1.02 (0.99 to 1.05)

1.02 (0.99 to 1.05)

  NSAIDs

11.2 (17.6)

15 (30.9)

9.6 (10.6)

13.9 (38)

9.4 (11.8)

10.6 (15)

11.1 (18.9)

8.9 (12.3)

9.9 (13.3)

12.6 (23.4)

0.98 (0.98 to 0.99)***

0.98 (0.98 to 0.99)***

  1. Outpatient visits and prescription days were provided with the mean (standard deviation) per one patient by year. Prevalence rates were provided with per 100 patients by the year. Prescription days were calculated for patients who were prescribed corresponding medication. Relative ratio (RR) was estimated with Poisson regression. We presented crude and age-adjusted RR per one year. RR of prescription days for dienogest was estimated with data after 2013. *P < 0.05; **P < 0.01; ***P < 0.001. GnRH, gonadotrophin-releasing hormone; NSAIDs, non-steroidal anti-inflammatory drugs. RR, relative ratio.