Figure 1 | Scientific Reports

Figure 1

From: Waning cellular immune responses and predictive factors in maintaining cellular immunity against SARS-CoV-2 six months after BNT162b2 mRNA vaccination

Figure 1

Dynamics of the cellular immune response as the IFN-γ level changes. Blood samples were collected and stimulated with Ag1 (upper) and Ag2 (lower) derived from the SARS-CoV-2 spike protein before and after full vaccination. The time-dependent change of IFN-γ levels, induced by the incubation of lymphocytes with SARS-CoV-2-specific epitopes of CD4 + (Ag1) or CD4 + and CD8 + (Ag2) T cells, were demonstrated. Baseline indicates before the first dose of vaccination, and 3 W means before the second dose. Then IFN-γ levels were also measured in blood samples 3 weeks (6 W), 2 months (3 M), 3 months (4 M), and 6 months (7 M) after the second vaccination. Box plots show the median and interquartile range associated with the min and max. The Friedman test was used to calculate the P values (****P < 0.0001).

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