Table 1 Fold changes and coefficient variations of the difference of normalized counts of the top 25 differentially expressed miRNAs identified by miRNAseq between CIN2+ or CIN3+ and the reference group (< CIN1).

From: miRNAs signature as potential biomarkers for cervical precancerous lesions in human papillomavirus positive women

miRNA

CIN2+ (n = 10)

CIN3 (n = 3)

% CV

FC

p-value

FC

p-value

miR-133a-3p

6.9

 < 0.001

3.5

0.001

44

miR-143-5p

5

 < 0.001

2.7

0.008

30

miR-143-3p

5.1

 < 0.001

2.6

0.011

19

miR-145-5p

4.8

 < 0.001

2.5

0.018

22

miR-145-3p

4.5

 < 0.001

2.3

0.032

30

miR-1-3p

4.4

 < 0.001

3.1

0.002

48

miR-9-3p

3.3

 < 0.001

1.9

0.079

26

miR-99a-3p

3.4

0.001

1.9

0.096

25

miR-376b-3p

3.8

0.001

2

0.069

36

miR-125b-2-3p

2.8

0.001

1.7

0.145

21

let-7c-5p

3

0.001

1.9

0.095

13

miR-4329

2.4

0.002

1.6

0.149

18

miR-29a-3p

2.6

0.002

1.7

0.137

10

miR-28-3p

2.5

0.002

1.9

0.066

13

miR-125b-5p

2.9

0.002

1.7

0.158

12

miR-199a-5p

3.1

0.002

1.6

0.214

18

miR-9-5p

3.2

0.002

1.7

0.15

25

miR-214-5p

3.1

0.002

1.6

0.205

29

miR-619-3p

2.1

0.002

1.4

0.281

15

miR-381-3p

3.2

0.002

1.7

0.144

28

miR-195-3p

2.9

0.002

1.6

0.197

27

miR-30b-5p

2.1

0.002

1.7

0.085

9

miR-99a-5p

2.8

0.003

1.6

0.184

14

miR-204-5p

2.9

0.003

1.9

0.089

25

miR-10b-3p

2.4

0.003

1.8

0.111

19

  1. The p-values attained by the Wald statistic test are corrected for multiple testing using the Benjamini and Hochberg method by default in the DESeq2 package in use at the Data Analysis Center (Qiagen); CV coefficient of variation (n = 20 samples) of the normalized counts for each miRNA. miRNAs bolded were validated by qRT-PCR. FC fold change (CIN2+/ ≤ CIN1), or (only CIN3/≤ CIN1).
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