Table 2 Multivariate logistic regression analysis for CIN2+ and CIN3+ prediction by miRNAs only or in combination with HPV 16 and/or HPV 18 genotypes.
Variable selection method | miRNA | CIN2+ (n = 79) ref. ≤ CIN1 (n = 79) | CIN3+ (n = 27) ref. ≤ CIN1 (n = 79) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
pa | OR | 95% CI | AUC | 95% CI | pb | pa | OR | 95% CI | AUC | 95% CI | pb | ||||||
Enter | miR-143-5p | 0.018 | 1.357 | 1.055 | 1.747 | 0.645 | 0.565 | 0.719 | < 0.001 | 0.410 | 1.162 | 0.813 | 1.661 | 0.649 | 0.551 | 0.739 | 0.011 |
miR-29a-3p | 0.129 | 0.825 | 0.644 | 1.058 | 0.321 | 0.855 | 0.627 | 1.165 | |||||||||
miR-133a-3p | 0.264 | 0.900 | 0.749 | 1.083 | 0.745 | 0.959 | 0.745 | 1.235 | |||||||||
miR-143-3p | 0.630 | 0.942 | 0.739 | 1.201 | 0.515 | 1.132 | 0.779 | 1.646 | |||||||||
miR-30b-5p | 0.608 | 1.072 | 0.822 | 1.399 | 0.622 | 1.091 | 0.770 | 1.547 | |||||||||
Backward | miR-143-5p | 0.015 | 1.235 | 1.041 | 1.464 | 0.613 | 0.533 | 0.690 | 0.007 | 0.074 | 1.155 | 0.986 | 1.353 | 0.621 | 0.522 | 0.713 | 0.061 |
miR-29a-3p | 0.049 | 0.820 | 0.673 | 0.999 | – | – | – | – | |||||||||
CIN2 + (n = 78) ref. ≤ CIN1 (n = 72) | CIN3 + (n = 27) ref. ≤ CIN1 (n = 72) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Enter | miR-143-5p | 0.020 | 1.355 | 1.048 | 1.751 | 0.678 | 0.596 | 0.751 | < 0.001 | 0.179 | 1.196 | 0.837 | 1.833 | 0.726 | 0.628 | 0.811 | < 0.001 |
miR-29a-3p | 0.048 | 0.749 | 0.563 | 0.997 | 0.214 | 0.803 | 0.568 | 1.135 | |||||||||
miR-133a-3p | 0.378 | 0.918 | 0.758 | 1.111 | 0.804 | 0.968 | 0.746 | 1.256 | |||||||||
miR-143-3p | 0.836 | 1.028 | 0.791 | 1.336 | 0.362 | 1.212 | 0.801 | 1.833 | |||||||||
miR-30b-5p | 0.728 | 1.051 | 0.793 | 1.393 | 0.734 | 1.065 | 0.739 | 1.535 | |||||||||
HPV16 and/or18 | 0.035 | 2.097 | 1.054 | 4.173 | 0.023 | 3.068 | 1.171 | 8.039 | |||||||||
Backward | miR-143-5p | 0.004 | 1.313 | 1.093 | 1.578 | 0.660 | 0.578 | 0.735 | < 0.001 | 0.036 | 1.240 | 1.015 | 1.528 | 0.704 | 0.604 | 0.791 | < 0.001 |
miR-29a-3p | 0.016 | 0.752 | 0.597 | 0.947 | – | – | – | – | |||||||||
HPV16 and/or18 | 0.031 | 2.123 | 1.071 | 4.209 | 0.022 | 3.015 | 1.172 | 7.757 | |||||||||
