Table 1 Potential protein targets of the selected plants compounds.

From: Forecasting of potential anti-inflammatory targets of some immunomodulatory plants and their constituents using in vitro, molecular docking and network pharmacology-based analysis

UniProtKB entry ID	Gene ID	Protein name	Interacting compound(s)	combined interacting score
P33527	ABCC1	Multidrug resistance-associated protein 1	Nobiletin	0.8
			Bisdemethoxycurcumin	0.8
			5,7,3′,4′-tetramethoxyflavone	0.7
			Chrysoeriol	0.783
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Urolithin A	0.8
			Diallyl trisulfide	0.84
			Apigenin	0.876
P42574	CASP3	Caspase-3	Thymoquinone	0.822
			Diallyl trisulfide	0.945
			Guaiazulene	0.7
			Oleanolic acid	0.735
			Apigenin	0.947
P24385	CCND1	G1/S-specific cyclin-D1	Silibinin	0.824
P24941	CDK2	Cyclin-dependent kinase 2	Luteoin	0.942
P24941	CDK2	Cyclin-dependent kinase 2	Geraniol	0.8
P35222	CTNNB1	Catenin beta-1 (Beta-catenin)	Silibinin	0.831
P01133	EGF	Epidermal growth factor	Prunetin	0.8
P01100	FOS	Proto-oncogene c-Fos	Luteolin	0.944
P28223	HTR2A	5-hydroxytryptamine receptor 2A	Glabrene	0.8
			2,4-dihydroxybenzoic acid	0.8
			Homovanillic acid	0.862
P05362	ICAM1	Intercellular adhesion molecule 1	Glabridin	0.8
P22301	IL10	Interleukin-10	Aspirin	0.954
P05112	IL4	Interleukin-4	Ellagic acid	0.834
P05412	JUN	Transcription factor AP-1	Luteolin	0.946
P28482	MAPK1	Mitogen-activated protein kinase 1	Allicin	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	Ar-turmerone	0.8
P27361	MAPK3	Mitogen-activated protein kinase 3	Allicin	0.7
P45983	MAPK8	Mitogen-activated protein kinase 8	Luteolin	0.951
P08253	MMP2	72 kDa type IV collagenase	Nobiletin	0.8
			Diallyl trisulfide	0.943
			Gallic acid	0.951
			Kaempferol	0.815
			Galangin	0.8
			Silibinin	0.825
P14780	MMP9	Matrix metalloproteinase-9	Nobiletin	0.818
			Vanillin	0.8
			Luteolin	0.949
			Apigenin	0.842
			Aspirin	0.961
			Silibinin	0.855
P42345	MTOR	Serine/threonine-protein kinase mTOR	Galangin	0.734
P01106	MYC	Myc proto-oncogene protein	Nobiletin	0.8
P29475	NOS1	Nitric oxide synthase, brain	Bisdemethoxycurcumin	0.596
			Thymoquinone	0.596
			Glabridin	0.786
			Oleocanthal	0.786
			Caffeic acid phenethyl ester	0.406
P35228	NOS2	Nitric oxide synthase, inducible	Bisdemethoxycurcumin	0.733
			Thymoquinone	0.733
			Allicin	0.733
			Oleocanthal	0.613
			Caffeic acid phenethyl ester	0.425
P29474	NOS3	Nitric oxide synthase, endothelial	Bisdemethoxycurcumin	0.596
			Diallyl trisulfide	0.938
			Aspirin	0.957
			Oleocanthal	0.613
			Caffeic acid phenethyl ester	0.406
			Ellagic acid	0.828
			Sesamol	0.817
P60484	PTEN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	Thymoquinone	0.85
P35354	PTGS2	Prostaglandin G/H synthase 2	Catechin	0.833
			Thymoquinone	0.8
			Diallyl trisulfide	0.824
			Aspirin	0.999
			Sesamol	0.82
			Maslinic acid	0.8
			Apigenin	0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	Silibinin	0.822
P12931	SRC	Proto-oncogene tyrosine-protein kinase Src	Carnosic acid	0.8
P04637	TP53	Cellular tumor antigen p53	Aspirin	0.97
			Chrysin	0.722
			Silibinin	0.85
			Apigenin	0.868
O75762	TRPA1	Transient receptor potential cation channel subfamily A member 1	1,4-cineole	0.829
			Eugenol	0.873
			Allicin	0.962
			Zingerone	0.43
			1,8-cineole	0.837
P19320	VCAM1	Vascular cell adhesion protein 1	Galangin	0.8
P15692	VEGFA	Vascular endothelial growth factor A	Nobiletin	0.8
P15692	VEGFA	Vascular endothelial growth factor A	Carnosic acid	0.8

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Table 1 Potential protein targets of the selected plants compounds.

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