Table 2 KEGG pathway analysis of potential target genes functions42,43,44.

From: Forecasting of potential anti-inflammatory targets of some immunomodulatory plants and their constituents using in vitro, molecular docking and network pharmacology-based analysis

#Term ID

Term description

Observed gene count

False discovery rate

Matching proteins in network (labels)

hsa05200

Pathways in cancer

31

8.49E-16

MAPK1, HMOX1, MMP2, CCND1, IL4, RAF1, MAPK3, EGF, CDK2, TP53, PPARG, PTGER1, FOS, CYCS, CASP3, NQO1, NOS2, CTNNB1, MTOR, PTGS2, JUN, PTEN, MMP9, PIM1, MAPK8, NFE2L2, GSTP1, ESR1, AKT1, VEGFA, MYC

hsa05418

Fluid shear stress and atherosclerosis

18

1.21E-14

HMOX1, MMP2, MAPK14, ICAM1, TP53, VCAM1, NOS3, FOS, NQO1, CTNNB1, JUN, MMP9, SRC, MAPK8, NFE2L2, GSTP1, AKT1, VEGFA

hsa04926

Relaxin signaling pathway

15

1.08E-11

MAPK1, MMP2, MAPK14, RAF1, MAPK3, NOS3, FOS, NOS2, JUN, MMP9, SRC, MAPK8, AKT1, NOS1, VEGFA

hsa04657

IL-17 signaling pathway

12

5.05E-10

MAPK1, MAPK14, IL4, MAPK3, CCL11, FOS, CASP3, PTGS2, S100A8, JUN, MMP9, MAPK8

hsa04068

FoxO signaling pathway

13

1.33E-09

MAPK1, CCND1, MAPK14, CAT, RAF1, MAPK3, EGF, CDK2, PLK1, PTEN, MAPK8, IL10, AKT1

hsa04210

Apoptosis

13

1.76E-09

MAPK1, RAF1, MAPK3, BCL2A1, TP53, FOS, CYCS, CASP3, PARP1, MCL1, JUN, MAPK8, AKT1

hsa04668

TNF signaling pathway

12

1.93E-09

MAPK1, MAPK14, MAPK3, ICAM1, VCAM1, FOS, CASP3, PTGS2, JUN, MMP9, MAPK8, AKT1

hsa04012

ErbB signaling pathway

10

2.50E-08

MAPK1, RAF1, MAPK3, EGF, MTOR, JUN, SRC, MAPK8, AKT1, MYC

hsa04370

VEGF signaling pathway

9

2.50E-08

MAPK1, MAPK14, RAF1, MAPK3, NOS3, PTGS2, SRC, AKT1, VEGFA

hsa04115

p53 signaling pathway

9

6.38E-08

CCND1, CDK2, TP53, CYCS, CASP3, PTEN, IGFBP3, CDK1, CHEK1

hsa04660

T cell receptor signaling pathway

10

9.09E-08

MAPK1, MAPK14, IL4, RAF1, MAPK3, FOS, BCL10, JUN, IL10, AKT1

hsa01521

EGFR tyrosine kinase inhibitor resistance

9

1.51E-07

MAPK1, RAF1, MAPK3, EGF, MTOR, PTEN, SRC, AKT1, VEGFA

hsa04071

Sphingolipid signaling pathway

10

3.04E-07

MAPK1, MAPK14, RAF1, MAPK3, TP53, NOS3, PTEN, MAPK8, ABCC1, AKT1

hsa04010

MAPK signaling pathway

14

6.84E-07

MAPK1, MAPK14, RAF1, MAPK3, EGF, TP53, FOS, CASP3, JUN, RPS6KA3, MAPK8, AKT1, VEGFA, MYC

hsa04066

HIF-1 signaling pathway

9

7.67E-07

MAPK1, HMOX1, MAPK3, EGF, NOS3, NOS2, MTOR, AKT1, VEGFA

hsa04151

PI3K-Akt signaling pathway

15

8.03E-07

MAPK1, CCND1, IL4, RAF1, MAPK3, EGF, CDK2, TP53, NOS3, MTOR, MCL1, PTEN, AKT1, VEGFA, MYC

hsa04371

Apelin signaling pathway

10

8.30E-07

MAPK1, CCND1, RAF1, UCP1, MAPK3, NOS3, NOS2, MTOR, AKT1, NOS1

hsa04722

Neurotrophin signaling pathway

9

2.48E-06

MAPK1, MAPK14, RAF1, MAPK3, TP53, JUN, RPS6KA3, MAPK8, AKT1

hsa04630

Jak-STAT signaling pathway

10

3.50E-06

CCND1, IL4, RAF1, EGF, MTOR, MCL1, PIM1, IL10, AKT1, MYC

hsa04611

Platelet activation

9

3.58E-06

MAPK1, MAPK14, MAPK3, PTGIR, NOS3, PTGS1, SRC, TBXA2R, AKT1

hsa04664

Fc epsilon RI signaling pathway

7

6.10E-06

MAPK1, MAPK14, IL4, RAF1, MAPK3, MAPK8, AKT1

hsa04659

Th17 cell differentiation

8

8.12E-06

MAPK1, MAPK14, IL4, MAPK3, FOS, MTOR, JUN, MAPK8

hsa04662

B cell receptor signaling pathway

7

8.38E-06

MAPK1, RAF1, MAPK3, FOS, BCL10, JUN, AKT1

hsa04064

NF-kappa B signaling pathway

7

3.68E-05

CSNK2A1, ICAM1, BCL2A1, VCAM1, PARP1, PTGS2, BCL10

hsa04620

Toll-like receptor signaling pathway

7

6.25E-05

MAPK1, MAPK14, MAPK3, FOS, JUN, MAPK8, AKT1

hsa04022

cGMP-PKG signaling pathway

8

0.00013

MAPK1, RAF1, MAPK3, SLC25A4, NOS3, SLC25A5, SLC25A6, AKT1

hsa04062

Chemokine signaling pathway

8

0.00028

MAPK1, RAF1, MAPK3, PPBP, CCL11, SRC, HCK, AKT1

hsa04750

Inflammatory mediator regulation of TRP channels

6

0.00028

MAPK14, TRPA1, SRC, MAPK8, HTR2A, VR1

hsa04310

Wnt signaling pathway

7

0.0004

CSNK2A1, CCND1, TP53, CTNNB1, JUN, MAPK8, MYC

hsa04150

mTOR signaling pathway

7

0.00048

MAPK1, RAF1, MAPK3, MTOR, PTEN, RPS6KA3, AKT1

hsa04920

Adipocytokine signaling pathway

5

0.0006

MTOR, MAPK8, PPARA, ADIPOQ, AKT1

hsa04670

Leukocyte transendothelial migration

6

0.0007

MMP2, MAPK14, ICAM1, VCAM1, CTNNB1, MMP9

hsa04910

Insulin signaling pathway

6

0.0016

MAPK1, RAF1, MAPK3, MTOR, MAPK8, AKT1

hsa04666

Fc gamma R-mediated phagocytosis

5

0.0017

MAPK1, RAF1, MAPK3, HCK, AKT1

hsa04621

NOD-like receptor signaling pathway

6

0.004

MAPK1, NAMPT, MAPK14, MAPK3, JUN, MAPK8

hsa04014

Ras signaling pathway

7

0.0043

MAPK1, RAF1, MAPK3, EGF, MAPK8, AKT1,VEGFA

hsa04152

AMPK signaling pathway

5

0.005

CCND1, PPARG, MTOR, ADIPOQ, AKT1

hsa04650

Natural killer cell mediated cytotoxicity

5

0.0057

MAPK1, RAF1, MAPK3, ICAM1, CASP3

hsa05323

Rheumatoid arthritis

4

0.008

ICAM1, FOS, JUN, VEGFA

hsa04060

Cytokine-cytokine receptor interaction

6

0.0283

IL4, EGF, PPBP, CCL11, IL10, VEGFA

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