Figure 3 | Scientific Reports

Figure 3

From: GLP‑1 receptor agonist protects palmitate-induced insulin resistance in skeletal muscle cells by up-regulating sestrin2 to promote autophagy

Figure 3

Liraglutide activates PA-induced L6 myotubes autophagy and up-regulates SESN2 expression. (A) and (B) The mRNA levels of LC3II and P62 in L6 myotubes were determined by RT-qPCR. (C) and (D) The protein levels of LC3II/LC3I and P62 in L6 myotubes were determined using western blotting. The (E) mRNA and (F) protein levels of SESN2 in L6 myotubes were determined using RT-qPCR and western blotting. The results are expressed as means ± S.D. of three independent experiments. *P < 0.05 vs con; #P < 0.05 vs PA; △P < 0.05 vs Lir10.

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