Figure 5 | Scientific Reports

Figure 5

From: GLP‑1 receptor agonist protects palmitate-induced insulin resistance in skeletal muscle cells by up-regulating sestrin2 to promote autophagy

Figure 5

Lilarutide ameliorates palmitate PA-induced IR and autophagy via SESN2. The (A) mRNA and (B) protein levels of SESN2 in L6 myotubes were determined by quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) and western blot. (C) and (D) The protein levels of LC3B and P62 in L6 myotubes were determined using RT-qPCR. (E) and (F) The mRNA levels of LC3II/LC3I and P62 in L6 myotubes were determined using western blotting. The results are expressed as means ± S.D. of three independent experiments. *P < 0.05 vs siCON.

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