Figure 7 | Scientific Reports

Figure 7

From: GLP‑1 receptor agonist protects palmitate-induced insulin resistance in skeletal muscle cells by up-regulating sestrin2 to promote autophagy

Figure 7

Schematic diagram of the mechanism of liralutide in reducing IR in skeletal muscle. PA suppresses SESN2 expression, leading to downregulation of autophagy which further impaired phosphorylation of Akt and expression of GLUT4. As a result, causing L6 cells IR. Liraglutide improved PA-induced IR in L6 myotubes by increasing autophagy-mediated by SESN2.

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