Table 1 Cellular effectors involved in rejecting Lsal in Okis fin based on significant differential expression profiling of cellular markers and known effector molecules.

NCCs (Teleost NK-cell equivalent)

↑ nccrp-1

1 → 7 dpi

Antigen-dependent cytotoxicity

↑ graa

4 → 7 dpi

Activates cell death

↑ aep1

1 → 7 dpi

Pore-forming protein

T cells

↑ cd4

7 dpi

Activation of Th cells

↑ cd5

7 → 10 dpi

Th17 regulation

↑ cd33

7 dpi

T cell inhibition

↑ cd59

1 dpi

T cell activation

↓ cd82

7 → 16 dpi

Co-stimulatory with TCR/CD3

↑ cd166

7 dpi

T cell activation

↑ cd226

7 dpi

CTL/NK signalling

↑ cd247

10 dpi

TCR/CD3 complex

↑ cd276

1 dpi

Enhances CTL

↑ cxcl11

1 → 10 dpi

Chemotactic for activated T cells

B cells

↑ cd22

1 → 10 dpi

Lymphocyte interactions (B and T cells); regulator of B

↓ cd22

16 dpi

cells

↑ cd53

1 → 10 dpi

Mature B cells

Neutrophils

↑ cxcr1

4 → 10 dpi

Receptor for IL8, powerful neutrophil chemotactic factor

↑ ileu

1 → 10 dpi

Regulates activity of neutrophil proteases

↑ lect2

1 → 10 dpi

Neutrophil chemotaxis

↑ ncf1

1 → 10 dpi

Necessary for superoxide production

↑ ncf2

1 → 10 dpi

Necessary for superoxide production

Mast cells

↑ fcεriγ

1 → 16 dpi

Transducing subunit of FCεRI

↑ cd63

1 → 10 dpi

MC degranulation

↑ ckit

1 → 7 dpi

Tyrosine kinase growth factor receptor; role in MC development; enhances degranulation

↑ fyn

4 → 10 dpi

Regulates MC degranulation

↑ lyn

1 → 16 dpi

Interacts with FCeRI

↑ syk

6 → 10 dpi

Protein kinase, transducer of FCeRI signalling

Dendritic cells

↑ cd209

1 → 10 dpi

Presents Ag to T cells via MHII

↑ c1qb

7 dpi → 16 dpi

Bonafide DC marker; regulates hyperactive allergic responses

Macrophages

↑ arg1

4 → 10 dpi

Alternatively activated macrophage marker

↑ mrc1

4 → 10 dpi

Endocytosis of glycoproteins; cognate chitin receptor