Figure 5
From: Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma
Evaluation of in vivo effects of SFXN1 attenuation on lipotoxicity. (A) Tumorigenicity assay of the SFXN1-KO HCC cells in immunodeficient mice fed with HFD. The left and right panels show tumor growth curves and relative tumor volumes at five weeks. P-values are calculated by Welch’s t-test. Data are the mean ± SE. (B) Immunohistochemical analysis of tumor tissues derived from the SFXN1-KO HCC cells in immunodeficient mice with HFD. The left and right panels show representative immunohistochemical images and quantitative data of the percentage of Ki-67-positive cells (Ki-67 labeling index), respectively. Arrowheads indicate TUNEL-positive cells. ND: normal diet; HFD: high-fat diet; NS: not significant.
