Figure 5 | Scientific Reports

Figure 5

From: Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease

Figure 5The alternative text for this image may have been generated using AI.

Percentages of voxels per ROI belonging to one of 7 categories for the LCN CAP (A (3 M), C(6 M), E(10 M)) and the DMLN CAP (B (3 M), D(6 M), F(10 M)) respectively. The red & blue colour bars indicate significant co-activation and co-deactivation, respectively, in either the WT or the HET group. Different colour/shade bars indicate percentage of voxels from seven different categories: (a) significant co-activation and higher activation magnitude in WT, (b) significant co-activation and no significant inter-genotype difference in the activation magnitude, (c) significant co-activation and higher activation magnitude in HET, (d) significant co-deactivation and higher activation magnitude in WT, (e) significant co-deactivation and no significant inter-genotype difference in the activation magnitude, (f) significant co-deactivation and higher activation magnitude in HET, and (g) non-significant co-activation or co-deactivation during a CAP. Voxel-wise one-sample T-test (p < 0.01, Bonferroni corrected) and two-sample T-test (p < 0.05, FDR corrected) are performed across occurrences of a CAP within the concatenated genotypic image-series from all subjects to identify the voxels belonging to one of the 7 categories mentioned above in the entire brain. We then calculate the percentages of each category in each of the 28 ROIs shown in Figs. 2M, 3J, 4S. ROIs belonging to the DMLN have red labels, ROIs belonging to the associated cortical network have magenta labels while the blue labels represent LCN ROIs. The black labels represent the rest of the cortical and sub-cortical ROIs.

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