Figure 6 | Scientific Reports

Figure 6

From: Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies

Figure 6

Well-differentiated HBE culture transcriptomics. (a) Venn diagram comparing the top 10% gene expression of the stiffest 3D OTE model, 2D ALI culture, and in vivo human airway epithelium (Normal HBE)44. (b) Volcano plot displaying differentially expressed transcripts of the stiff 3D OTE model in comparison to 2D ALI culture. (c) Expression regulation breakdown of the genes from the gene expression signatures of ciliated, secretory, and basal cells for the stiff 3D OTE model in comparison to 2D ALI culture. (d) Transcriptomic comparison of the fold change of the top 15 expressed gene markers related to HBE subtypes between the stiff 3D OTE model and 2D ALI culture (n = 3).

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