Table 1 Anti-α-glucosidase activity of new phthalimide derivatives 11a–n in comparison with positive control acarbose.

From: Design, synthesis, in vitro anti-α-glucosidase evaluations, and computational studies of new phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides as potential anti-diabetic agents

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Compound

R

n

IC50 (µM)a

11a

H

0

203.78 ± 0.32

11b

2,3-Dimethyl

0

366.10 ± 0.86

11c

2,6-Dimethyl

0

750 < 

11d

4-Ethyl

0

491.68 ± 0.11

11e

3-F

0

188.35 ± 0.27

11f

3-Cl

0

112.16 ± 0.03

11g

2,3-Dichloro

0

239.10 ± 0.41

11h

2,4-Dichloro

0

283.98 ± 0.41

11i

2,6-Dichloro

0

46.25 ± 0.89

11j

4-Br

0

45.26 ± 0.03

11k

4-Nitro

0

750 < 

11l

2-Methyl-4-nitro

0

273.29 ± 0.28

11m

H

1

750 < 

11n

4-F

1

685.99 ± 0.32

Acarbose

-

-

750.1 ± 0.23

  1. aIC50 values are indicated as the mean ± SD of three independent experiments.
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