Table 1 Summary of the drugs under study characterization at the molecular level.

From: Application of systems biology to identify pharmacological mechanisms of thrombotic microangiopathy evoked by combined activated prothrombin complex concentrate and emicizumab

Drug

DrugBank ID

Protein name

Short name

UniProt

Action

Emi

DB13923

Coagulation factor X

FX

P00742

↑

rFVIIa

DB00036

Coagulation factor VII

FVII

P08709

↑

aPCC

DB13151

Prothrombin

FII

P00734

↑

Coagulation factor VII

FVII

P08709

↑

Coagulation factor IX

FIX

P00740

↑

Coagulation factor X

FX

P00742

↑

Kininogen-1

KNG1

P01042

↑

Kallikrein-1 (tissue kallikrein)

KLK1

P06870

↑

  1. The effect of the drug over the proposed target is indicated by an arrow (up = activation).
  2. aPCC activated prothrombin complex concentrate, Emi emicizumab, rFVIIa recombinant activated factor VII.