Figure 3

Additional traits are associated with SARS-CoV-2 infection severity in blood and brain. The protein interaction network analysis (Fig. 1b) was applied to whole blood and brain tissues using genes (i.e. severe = 206; hospitalised = 214 in blood, severe = 35; hospitalised = 38 in brain; Supplementary Fig. 1d; Supplementary Table 6) targeted by SARS-CoV-2 associated eQTLs in these tissues (Supplementary Table 6), blood³⁹ and brain GRNs (Supplementary Table 7). Blood tissue traits identified from the STRING protein interactions that were (a) shared across both severe and hospitalised phenotypes; and (b) were shared and observed in the brain. Only traits that were significant following bootstrapping (p ≤ 0.05) are shown. Bubble size is proportional to the total number of eQTLs enriched in each trait, bubble colour is proportional to the adjusted p-value (Bonferroni correction) for GWAS trait enrichment. The heatmaps highlight genes that are associated with the level 0 traits in the severe (c) and hospitalised (d) phenotypes in the brain.